منابع مشابه
Assessment of the Physicochemical Properties and In Vitro Dissolution of Glibenclamide Tablets Marketed in Saudi Arabia
Glibenclamide (GBD), also known as glyburide, is an oral hypoglycemic of the sulfonylurea group that is frequently prescribed for the treatment of noninsulin dependent diabetes mellitus. The aim of this study was to assess the pharmaceutical quality of new formulations and four generic marketed glibenclamide tablets in Saudi Arabia in comparison with the innovator product (Daonil tablets). Fria...
متن کاملDevelopment and Validation of a Dissolution Test for Telithromycin in Coated Tablets
A dissolution test for telithromycin tablets was validated and developed. In order to choose the most discriminatory one, the conditions to carry out are 900 mL of sodium phosphate buffer at pH 7.5, paddles at 50 rpm stirring speed, time test set to 60 min and using USP apparatus 2 with paddles. The UV spectrophotometric method for determination of telithromycin released was developed and valid...
متن کاملDevelopment and Validation of a Dissolution Test for 6 mg Deflazacort Tablets
The aim of this study was to develop and validate a dissolution test for the quality control of deflazacort (DEF) tablets, a drug mainly used for the prevention of organ transplantation rejection, labeled as containing 6 mg of active pharmaceutical ingredient (API), using an RP-HPLC method. After testing sink conditions and stability at 37°C, DEF was found to be unstable, and decomposed as a fu...
متن کاملDevelopment and Validation of Discriminating and Biorelevant Dissolution Test for Lornoxicam Tablets
The establishment of biorelevant and discriminating dissolution procedure for drug products with limited water solubility is a useful technique for qualitative forecasting of the in vivo behavior of formulations. It also characterizes the drug product performance in pharmaceutical development. Lornoxicam, a BCS class-II drug is a nonsteroidal antiinflammatory drug of the oxicam class, has no of...
متن کاملDiscriminatory Dissolution Test for Tablets Containing a- and b-Thalidomide Polymorphs
Over the years, thalidomide has been prescribed for an increasing number of diseases, including multiple myeloma and erythema nodosum leprosum. In Brazil and other countries, thalidomide is available in tablets, and there is no official dissolution testing available for this dosage form. Considering this, a dissolution method was developed and validated for tablets containing 100 mg of each pol...
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ژورنال
عنوان ژورنال: Química Nova
سال: 2007
ISSN: 0100-4042
DOI: 10.1590/s0100-40422007000500031